PRKD3

Entrez Summary: N/A
UniProt Summary: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.02
RS-1 10μM R08 exp519	2.05

protein kinase D signaling
protein kinase C activity
protein kinase C-activating G protein-coupled receptor signaling pathway
kinase activity
sphingolipid biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
lipid biosynthetic process
cellular lipid metabolic process
protein phosphorylation
lipid metabolic process
phosphorylation
G protein-coupled receptor signaling pathway
organonitrogen compound biosynthetic process
ATP binding
intracellular signal transduction
membrane