PRMT6

Gene Information

Official Symbol: PRMT6
Official Name: protein arginine methyltransferase 6
Aliases and Previous Symbols: N/A
Entrez ID: 55170
UniProt: Q96LA8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting- induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). {ECO:0000250, ECO:0000269|PubMed:11724789, ECO:0000269|PubMed:16157300, ECO:0000269|PubMed:16159886, ECO:0000269|PubMed:16600869, ECO:0000269|PubMed:17267505, ECO:0000269|PubMed:17898714, ECO:0000269|PubMed:18077460, ECO:0000269|PubMed:18079182, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:19509293, ECO:0000269|PubMed:20047962}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4680
Expression level (log2 read counts): 5.09

Expression Distribution

Screen	Score
R-DABN 8μM R03 exp111	1.76
Tenofovir 10μM R07 exp405	1.77
Apcin 50 to 100μM on day4 R04 exp176	1.83

PRMT5
Methyltransf 9
MTS
Methyltransf 18
PrmA

histone methyltransferase activity (H3-R2 specific)
histone methyltransferase activity (H2A-R3 specific)
histone H3-R2 methylation
histone methyltransferase activity (H4-R3 specific)
negative regulation of histone H3-K4 methylation
protein-arginine omega-N monomethyltransferase activity
histone H4-R3 methylation
protein-arginine N-methyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
histone-arginine N-methyltransferase activity
peptidyl-arginine omega-N-methylation
histone methyltransferase activity
peptidyl-arginine N-methylation
histone arginine methylation
peptidyl-arginine methylation
negative regulation of histone methylation
peptidyl-arginine modification
regulation of histone H3-K4 methylation
cellular senescence
base-excision repair
negative regulation of histone modification
regulation of megakaryocyte differentiation
negative regulation of chromatin organization
cell aging
regulation of histone methylation
histone methylation
histone binding
negative regulation of chromosome organization
protein alkylation
protein methylation
regulation of histone modification
regulation of signal transduction by p53 class mediator
regulation of chromatin organization
regulation of myeloid cell differentiation
macromolecule methylation
aging
methylation
regulation of chromosome organization
histone modification