PRPF6

Entrez Summary: The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 703/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	54/56
cervix	4/4
colorectal	17/17
esophagus	12/13
fibroblast	1/1
gastric	15/15
kidney	20/21
liver	18/20
lung	73/75
lymphocyte	14/14
ovary	24/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	19/22
urinary tract	28/29
uterus	5/5

Expression Distribution

spliceosomal tri-snRNP complex assembly
U5 snRNP
ribonucleoprotein complex binding
U4/U6 x U5 tri-snRNP complex
spliceosomal snRNP assembly
androgen receptor binding
U2-type precatalytic spliceosome
spliceosomal complex assembly
catalytic step 2 spliceosome
spliceosomal complex
RNA localization
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
transcription coactivator activity
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
positive regulation of transcription by RNA polymerase II
RNA binding
positive regulation of transcription, DNA-templated
protein-containing complex assembly
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
positive regulation of RNA metabolic process
protein-containing complex subunit organization
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
membrane
gene expression
positive regulation of biosynthetic process