PRSS8

Entrez Summary: N/A
UniProt Summary: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). {ECO:0000269|PubMed:15246975, ECO:0000269|PubMed:15474520}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF1986
Trypsin

extrinsic component of plasma membrane
anchored component of plasma membrane
sodium channel regulator activity
positive regulation of sodium ion transport
serine-type peptidase activity
regulation of sodium ion transport
cornification
serine-type endopeptidase activity
keratinization
keratinocyte differentiation
positive regulation of ion transport
epidermal cell differentiation
skin development
regulation of metal ion transport
epidermis development
epithelial cell differentiation
regulation of ion transport
positive regulation of transport
programmed cell death
cell death
epithelium development
proteolysis
extracellular space
tissue development
regulation of transport
extracellular region