PSAT1

Entrez Summary: This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013].
UniProt Summary: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. {ECO:0000250|UniProtKB:P10658}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 7/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Expression Distribution

O-phospho-L-serine:2-oxoglutarate aminotransferase activity
pyridoxine metabolic process
pyridoxine biosynthetic process
vitamin B6 biosynthetic process
vitamin B6 metabolic process
L-serine biosynthetic process
water-soluble vitamin biosynthetic process
L-serine metabolic process
vitamin biosynthetic process
serine family amino acid biosynthetic process
pyridine-containing compound biosynthetic process
pyridine-containing compound metabolic process
serine family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
water-soluble vitamin metabolic process
vitamin metabolic process
organic hydroxy compound biosynthetic process
alpha-amino acid metabolic process
cofactor biosynthetic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
cofactor metabolic process
organic hydroxy compound metabolic process
drug metabolic process
small molecule biosynthetic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process