PSMG1

Entrez Summary: N/A
UniProt Summary: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 240/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	10/28
blood	6/28
bone	5/26
breast	15/33
central nervous system	14/56
cervix	1/4
colorectal	7/17
esophagus	8/13
fibroblast	0/1
gastric	5/16
kidney	2/21
liver	9/20
lung	19/75
lymphocyte	5/16
ovary	9/26
pancreas	12/24
peripheral nervous system	3/16
plasma cell	2/15
prostate	0/1
skin	12/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	10/22
urinary tract	13/29
uterus	2/5

Expression Distribution

proteasome core complex assembly
cerebellar granule cell precursor proliferation
cell proliferation in external granule layer
cell proliferation in hindbrain
proteasome assembly
proteasome binding
neural precursor cell proliferation
hindbrain development
cell population proliferation
brain development
head development
cellular protein-containing complex assembly
central nervous system development
Golgi apparatus
endoplasmic reticulum
protein-containing complex assembly
protein-containing complex subunit organization