PTCHD2

Entrez Summary: N/A
UniProt Summary: Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity). {ECO:0000250|UniProtKB:B9U3F2, ECO:0000269|PubMed:25281927}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BH1 1μM R04 exp169	1.75
MK-1775 0.32μM R02 exp75	1.95

positive regulation of neural precursor cell proliferation
smoothened signaling pathway
cholesterol homeostasis
sterol homeostasis
regulation of neural precursor cell proliferation
regulation of lipid transport
cholesterol metabolic process
secondary alcohol metabolic process
lipid homeostasis
sterol metabolic process
regulation of lipid localization
positive regulation of lipid metabolic process
cytoplasmic vesicle membrane
negative regulation of neuron differentiation
nuclear membrane
steroid metabolic process
negative regulation of neurogenesis
negative regulation of nervous system development
alcohol metabolic process
negative regulation of cell development
regulation of lipid metabolic process
organic hydroxy compound metabolic process
regulation of neuron differentiation
negative regulation of cell differentiation
molecular function
regulation of neurogenesis
positive regulation of cell population proliferation
regulation of nervous system development
regulation of cell development
endoplasmic reticulum membrane
negative regulation of developmental process
endoplasmic reticulum
chemical homeostasis
negative regulation of multicellular organismal process
lipid metabolic process
generation of neurons
regulation of cell population proliferation
neurogenesis
homeostatic process
small molecule metabolic process