PTGDR2

Entrez Summary: This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011].
UniProt Summary: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.71
Benzoate 10000μM R08 exp455	1.78

prostaglandin F receptor activity
prostaglandin D receptor activity
prostaglandin J receptor activity
negative regulation of germ cell proliferation
negative regulation of male germ cell proliferation
regulation of male germ cell proliferation
regulation of germ cell proliferation
neuropeptide binding
positive regulation of G protein-coupled receptor signaling pathway
peptide binding
negative regulation of reproductive process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
neuropeptide signaling pathway
regulation of G protein-coupled receptor signaling pathway
calcium-mediated signaling
regulation of reproductive process
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
negative regulation of multi-organism process
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
second-messenger-mediated signaling
chemotaxis
taxis
negative regulation of cell population proliferation
G protein-coupled receptor activity
regulation of multi-organism process
negative regulation of multicellular organismal process
locomotion
G protein-coupled receptor signaling pathway
integral component of plasma membrane
regulation of cell population proliferation
positive regulation of signal transduction
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling
immune response