PTGFR

Entrez Summary: The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. {ECO:0000250, ECO:0000269|PubMed:18587449}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cannabidiol 20μM R08 exp466	1.74
Chloramphenicol 2μM R00 exp12	2.26

prostaglandin F receptor activity
response to prostaglandin D
cellular response to prostaglandin D stimulus
parturition
cellular response to prostaglandin stimulus
calcium-mediated signaling using intracellular calcium source
response to prostaglandin
cellular response to fatty acid
response to fatty acid
cellular response to alcohol
cellular response to ketone
adenylate cyclase-activating G protein-coupled receptor signaling pathway
response to estradiol
calcium-mediated signaling
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
response to ketone
cellular response to acid chemical
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
multi-multicellular organism process
response to alcohol
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
response to lipopolysaccharide
response to molecule of bacterial origin
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
response to acid chemical
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
cellular response to lipid
cellular metal ion homeostasis
cellular response to hormone stimulus
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
response to bacterium