RAB14

Entrez Summary: N/A
UniProt Summary: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion. {ECO:0000250, ECO:0000269|PubMed:22595670}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Monensin 0.3μM R08 exp507	-3
CoCl2 18μM R07 exp346	-2.41
Vemurafenib 6.6μM R08 exp434	-2.08
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.04
CI-1040 9.5μM R08 exp472	-1.78
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.75
Q15 1 to 2μM on day4 R04 exp164	-1.72
Amiloride 100μM R08 exp447	1.84

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phagolysosome assembly involved in apoptotic cell clearance
nuclear outer membrane-endoplasmic reticulum membrane network
phagosome maturation involved in apoptotic cell clearance
phagolysosome assembly
trans-Golgi network transport vesicle
myosin V binding
Golgi to endosome transport
Golgi stack
endocytic recycling
apoptotic cell clearance
phagosome maturation
lysosome organization
lytic vacuole organization
rough endoplasmic reticulum
phagocytic vesicle
Rab protein signal transduction
tertiary granule membrane
GDP binding
fibroblast growth factor receptor signaling pathway
recycling endosome membrane
intracellular
post-Golgi vesicle-mediated transport
phosphatidylinositol biosynthetic process
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
recycling endosome
late endosome
regulation of embryonic development
vacuole organization
cytosolic transport
early endosome membrane
phosphatidylinositol metabolic process
trans-Golgi network
cilium
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
endosomal transport
phospholipid biosynthetic process
Ras protein signal transduction
lysosome