RAB6B

Entrez Summary: N/A
UniProt Summary: Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells. {ECO:0000269|PubMed:17707369}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.89
Alpha-Amanitin 0.5μM R00 exp5	1.95

myosin V binding
intra-Golgi vesicle-mediated transport
Rab protein signal transduction
endoplasmic reticulum-Golgi intermediate compartment
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
retrograde transport, endosome to Golgi
presynapse
cytosolic transport
endosomal transport
Ras protein signal transduction
cytoplasmic vesicle
small GTPase mediated signal transduction
GTPase activity
Golgi vesicle transport
GTP binding
Golgi membrane
Golgi apparatus
intracellular protein transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
intracellular signal transduction
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport