RAET1E

Gene Information

Official Symbol: RAET1E
Official Name: retinoic acid early transcript 1E
Aliases and Previous Symbols: N/A
Entrez ID: 135250
UniProt: Q8TD07
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011].
UniProt Summary: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:18544572}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13920
Expression level (log2 read counts): 1.28

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	-1.73
Rifampicin 1μM R00 exp31	1.88

natural killer cell lectin-like receptor binding
susceptibility to natural killer cell mediated cytotoxicity
T cell mediated cytotoxicity
natural killer cell mediated cytotoxicity
natural killer cell mediated immunity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated immunity
leukocyte mediated cytotoxicity
T cell mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
natural killer cell activation
positive regulation of cell killing
regulation of leukocyte mediated cytotoxicity
cell killing
regulation of cell killing
positive regulation of lymphocyte mediated immunity
positive regulation of leukocyte mediated immunity
regulation of lymphocyte mediated immunity
regulation of leukocyte mediated immunity
positive regulation of immune effector process
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of innate immune response
positive regulation of response to biotic stimulus
lymphocyte activation
external side of plasma membrane
regulation of innate immune response
regulation of immune effector process
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
adaptive immune response
regulation of defense response
innate immune response
leukocyte mediated immunity
regulation of multi-organism process
positive regulation of immune response