RAET1L

Gene Information

Official Symbol: RAET1L
Official Name: retinoic acid early transcript 1L
Aliases and Previous Symbols: N/A
Entrez ID: 154064
UniProt: Q5VY80
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. {ECO:0000269|PubMed:19658097, ECO:0000269|PubMed:28559451}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quercetin 20μM R08 exp517	-2.5
Campthothecin 0.001μM R06 exp270	-1.91
Salubrinal 20μM R07 exp399	-1.78
Dimethyl-Sulfoxide 1pc R03 exp120	1.76
NFN1 0.1μM R01 exp49	1.83
THZ531 0.11μM R07 exp409	1.92
Myriocin 25μM R06 exp293	1.99

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13956
Expression level (log2 read counts): -0.81

Expression Distribution

natural killer cell lectin-like receptor binding
susceptibility to natural killer cell mediated cytotoxicity
T cell mediated cytotoxicity
natural killer cell mediated cytotoxicity
natural killer cell mediated immunity
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated immunity
leukocyte mediated cytotoxicity
T cell mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
natural killer cell activation
positive regulation of cell killing
regulation of leukocyte mediated cytotoxicity
cell killing
regulation of cell killing
anchored component of membrane
positive regulation of lymphocyte mediated immunity
positive regulation of leukocyte mediated immunity
regulation of lymphocyte mediated immunity
regulation of leukocyte mediated immunity
positive regulation of immune effector process
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of innate immune response
positive regulation of response to biotic stimulus
lymphocyte activation
external side of plasma membrane
regulation of innate immune response
regulation of immune effector process
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
adaptive immune response
viral process
regulation of defense response
innate immune response
leukocyte mediated immunity