RASA3

Entrez Summary: N/A
UniProt Summary: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intrinsic component of the cytoplasmic side of the plasma membrane
calcium-release channel activity
negative regulation of Ras protein signal transduction
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
negative regulation of small GTPase mediated signal transduction
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
cytosolic calcium ion transport
regulation of sequestering of calcium ion
calcium ion transmembrane transport
regulation of Ras protein signal transduction
calcium ion transport
GTPase activator activity
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
divalent inorganic cation transport
regulation of cytosolic calcium ion concentration
regulation of small GTPase mediated signal transduction
MAPK cascade
signal transduction by protein phosphorylation
positive regulation of GTPase activity
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
regulation of GTPase activity
divalent inorganic cation homeostasis
negative regulation of intracellular signal transduction
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
positive regulation of hydrolase activity