RASA4

Entrez Summary: N/A
UniProt Summary: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of GTPase activity
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
cellular response to calcium ion
phospholipid binding
response to calcium ion
cellular response to metal ion
cellular response to inorganic substance
regulation of Ras protein signal transduction
GTPase activator activity
regulation of small GTPase mediated signal transduction
response to metal ion
MAPK cascade
signal transduction by protein phosphorylation
positive regulation of GTPase activity
negative regulation of hydrolase activity
regulation of GTPase activity
negative regulation of intracellular signal transduction
response to inorganic substance
positive regulation of hydrolase activity
negative regulation of catalytic activity
protein phosphorylation
negative regulation of molecular function
negative regulation of signal transduction
regulation of hydrolase activity
phosphorylation
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity
negative regulation of response to stimulus
intracellular signal transduction
positive regulation of molecular function
regulation of intracellular signal transduction