RBFOX3
Gene Information
- Official Symbol: RBFOX3
- Official Name: RNA binding fox-1 homolog 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 146713
- UniProt: A6NFN3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017].
- UniProt Summary: Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). {ECO:0000250|UniProtKB:Q8BIF2}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12242
- Expression level (log2 read counts): 3.02
RBFOX3 Expression in NALM6 Cells: 3.02
