RBL1

Gene Information

Official Symbol: RBL1
Official Name: RB transcriptional corepressor like 1
Aliases and Previous Symbols: N/A
Entrez ID: 5933
UniProt: P28749
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys- 20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14953
Expression level (log2 read counts): 6.55

Expression Distribution

Screen	Score
Thimerosal 0.85μM R08 exp529	1.72
MS023 2μM R03 exp134	1.74

RB A
RB B
DUF3452
Rb C

RNA polymerase II regulatory region DNA binding
negative regulation of cellular senescence
negative regulation of cell aging
regulation of cellular senescence
regulation of cell aging
promoter-specific chromatin binding
RNA polymerase II activating transcription factor binding
regulation of lipid kinase activity
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
chromatin
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
regulation of cell division
transcription factor complex
negative regulation of mitotic cell cycle phase transition
negative regulation of cell cycle phase transition
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
transcription factor binding
regulation of lipid metabolic process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
negative regulation of cell cycle
regulation of mitotic cell cycle
chromatin organization
viral process
regulation of cellular response to stress
regulation of cell cycle process
symbiotic process
interspecies interaction between organisms
negative regulation of transcription by RNA polymerase II
regulation of kinase activity
negative regulation of developmental process
regulation of transferase activity
chromosome organization
regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription