RBP1

Entrez Summary: This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
UniProt Summary: Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496). {ECO:0000269|PubMed:15632377, ECO:0000269|PubMed:22665496, ECO:0000269|PubMed:26900151, ECO:0000269|PubMed:28057518}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nocodazole 0.02μM R00 exp23	1.76
WNT3A 44ng/ml R08 exp537	1.92

all-trans-retinol binding
retinoid binding
vitamin A metabolic process
retinoic acid biosynthetic process
diterpenoid biosynthetic process
retinal binding
terpenoid biosynthetic process
isoprenoid biosynthetic process
retinoic acid metabolic process
fat-soluble vitamin metabolic process
lipid droplet
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
vitamin metabolic process
lipid homeostasis
isoprenoid metabolic process
monocarboxylic acid biosynthetic process
hormone metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
monocarboxylic acid metabolic process
regulation of hormone levels
lipid biosynthetic process
small molecule biosynthetic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
chemical homeostasis
lipid metabolic process
homeostatic process
small molecule metabolic process