REEP2

Entrez Summary: This gene encodes a member of the receptor expression enhancing protein family. Studies of a related gene in mouse suggest that the encoded protein is found in the cell membrane and enhances the function of sweet taste receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
UniProt Summary: Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity). {ECO:0000250, ECO:0000269|PubMed:24388663}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Chloramphenicol 2μM R00 exp12	-1.95
Arsenic trioxide 60μM R08 exp449	1.97

taste receptor binding
protein transport into membrane raft
sensory perception of sweet taste
protein transport within lipid bilayer
protein localization to membrane raft
endoplasmic reticulum tubular network organization
sensory perception of bitter taste
cytoplasmic microtubule
endoplasmic reticulum organization
sensory perception of taste
localization within membrane
establishment of protein localization to membrane
regulation of intracellular transport
endomembrane system organization
protein localization to membrane
sensory perception of chemical stimulus
membrane organization
regulation of cellular localization
endoplasmic reticulum membrane
sensory perception
intracellular protein transport
endoplasmic reticulum
nervous system process
integral component of plasma membrane
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
regulation of transport
system process