REXO4

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Tozasertib 0.1μM R07 exp414	-1.76
Taxol 0.002μM R01 exp54	2.02

DNA catabolic process, exonucleolytic
exonuclease activity
3-5 exonuclease activity
DNA catabolic process, endonucleolytic
DNA catabolic process
endonuclease activity
non-recombinational repair
single-stranded DNA binding
rRNA processing
rRNA metabolic process
transcription coactivator activity
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
nucleobase-containing compound catabolic process
ncRNA processing
nuclear speck
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
ncRNA metabolic process
organic cyclic compound catabolic process
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
nucleolus
RNA processing
cellular macromolecule catabolic process
macromolecule catabolic process
positive regulation of transcription by RNA polymerase II
RNA binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular response to stress
positive regulation of RNA metabolic process
organic substance catabolic process
cellular catabolic process
positive regulation of nucleobase-containing compound metabolic process