RFX1
Gene Information
- Official Symbol: RFX1
- Official Name: regulatory factor X1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5989
- UniProt: P22670
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016].
- UniProt Summary: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9480
- Expression level (log2 read counts): 3.71
RFX1 Expression in NALM6 Cells: 3.71
