RFX3
Gene Information
- Official Symbol: RFX3
- Official Name: regulatory factor X3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5991
- UniProt: P48380
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RFX1 trans act |
| RFX DNA binding |
GO Terms
| type B pancreatic cell maturation |
| positive regulation of type B pancreatic cell development |
| glandular epithelial cell maturation |
| columnar/cuboidal epithelial cell maturation |
| regulation of type B pancreatic cell development |
| epithelial cilium movement involved in determination of left/right asymmetry |
| type B pancreatic cell development |
| epithelial cell maturation |
| glandular epithelial cell development |
| type B pancreatic cell differentiation |
| enteroendocrine cell differentiation |
| epithelial cilium movement involved in extracellular fluid movement |
| extracellular transport |
| glandular epithelial cell differentiation |
| endocrine pancreas development |
| columnar/cuboidal epithelial cell development |
| positive regulation of epithelial cell differentiation |
| cilium movement |
| pancreas development |
| cilium or flagellum-dependent cell motility |
| cilium-dependent cell motility |
| columnar/cuboidal epithelial cell differentiation |
| determination of left/right symmetry |
| endocrine system development |
| determination of bilateral symmetry |
| specification of symmetry |
| anatomical structure maturation |
| regulation of epithelial cell differentiation |
| cell maturation |
| regulation of insulin secretion |
| microtubule-based transport |
| epithelial cell development |
| transcription factor complex |
| regulation of peptide hormone secretion |
| transcription regulatory region DNA binding |
| nuclear chromatin |
| developmental maturation |
| regulation of hormone secretion |
| microtubule-based movement |
| cilium assembly |
| cilium organization |
| pattern specification process |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| regulation of protein secretion |
| regulation of peptide secretion |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| regulation of hormone levels |
| positive regulation of cell development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| microtubule-based process |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| organelle assembly |
| regulation of secretion |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of protein localization |
| cell motility |
| localization of cell |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 | 1.73 |
| Nicotinamide 2000μM R01 exp50 | 1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7722
- Expression level (log2 read counts): 4.17
Expression Distribution
RFX3 Expression in NALM6 Cells: 4.17
