RHOT1

Gene Information

Official Symbol: RHOT1
Official Name: ras homolog family member T1
Aliases and Previous Symbols: N/A
Entrez ID: 55288
UniProt: Q8IXI2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7099
Expression level (log2 read counts): 4.99

Expression Distribution

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-1.84
Resminostat 0.5μM R07 exp393	1.72
Cannabidiol 13μM R08 exp465	1.75

EF assoc 1
Miro
Ras
EF assoc 2

microtubule polymerization based movement
establishment of mitochondrion localization by microtubule attachment
regulation of organelle transport along microtubule
mitochondrial outer membrane permeabilization
positive regulation of mitochondrial membrane permeability involved in apoptotic process
mitochondrial outer membrane permeabilization involved in programmed cell death
integral component of mitochondrial outer membrane
mitochondrion transport along microtubule
positive regulation of mitochondrial membrane permeability
establishment of mitochondrion localization, microtubule-mediated
regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of membrane permeability
establishment of mitochondrion localization
regulation of microtubule-based movement
mitochondrion localization
apoptotic mitochondrial changes
regulation of mitochondrial membrane permeability
Rho protein signal transduction
organelle transport along microtubule
regulation of membrane permeability
regulation of neurotransmitter secretion
mitochondrial membrane organization
regulation of neurotransmitter transport
transport along microtubule
mitochondrial outer membrane
cytoskeleton-dependent intracellular transport
regulation of mitochondrion organization
microtubule-based transport
mitochondrial transport
regulation of microtubule-based process
Ras protein signal transduction
microtubule-based movement
protein deubiquitination
apoptotic signaling pathway
protein modification by small protein removal
small GTPase mediated signal transduction
GTPase activity
regulation of small GTPase mediated signal transduction
regulation of intracellular transport
regulation of neurotransmitter levels