RND2

Entrez Summary: N/A
UniProt Summary: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
PF-06409577 20μM R07 exp389	1.74
Senexin-A 25μM R07 exp400	1.82

cell division site
positive regulation of collateral sprouting
establishment or maintenance of actin cytoskeleton polarity
establishment or maintenance of cytoskeleton polarity
acrosomal membrane
regulation of collateral sprouting
actin filament bundle assembly
actin filament bundle organization
Rho protein signal transduction
positive regulation of axonogenesis
protein N-terminus binding
regulation of extent of cell growth
cell cortex
regulation of cell shape
positive regulation of cell morphogenesis involved in differentiation
positive regulation of cell growth
positive regulation of developmental growth
regulation of cell size
regulation of axonogenesis
establishment or maintenance of cell polarity
actin filament organization
Ras protein signal transduction
early endosome
positive regulation of growth
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
small GTPase mediated signal transduction
regulation of developmental growth
GTPase activity
regulation of actin cytoskeleton organization
positive regulation of neuron differentiation
regulation of cellular component size
positive regulation of cell projection organization
regulation of actin filament-based process
GTP binding
regulation of cell growth
supramolecular fiber organization
protein kinase binding
positive regulation of neurogenesis
regulation of cell morphogenesis