RND3

Entrez Summary: N/A
UniProt Summary: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell division site
establishment or maintenance of actin cytoskeleton polarity
establishment or maintenance of cytoskeleton polarity
actin filament bundle assembly
actin filament bundle organization
Rho protein signal transduction
cell cortex
regulation of cell shape
establishment or maintenance of cell polarity
actin filament organization
Ras protein signal transduction
small GTPase mediated signal transduction
GTPase activity
regulation of actin cytoskeleton organization
regulation of actin filament-based process
GTP binding
focal adhesion
supramolecular fiber organization
protein kinase binding
regulation of cell morphogenesis
actin cytoskeleton organization
regulation of cytoskeleton organization
actin filament-based process
Golgi membrane
intracellular membrane-bounded organelle
regulation of cell migration
regulation of cell motility
cell adhesion
biological adhesion
regulation of locomotion
regulation of cellular component movement
regulation of anatomical structure morphogenesis
cytoskeleton organization
regulation of organelle organization
intracellular signal transduction