RNF157

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). {ECO:0000269|PubMed:25342469, ECO:0000269|PubMed:28655764}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of dendrite extension
regulation of dendrite extension
protein autoubiquitination
cell body
positive regulation of cell growth
positive regulation of developmental growth
ubiquitin protein ligase activity
positive regulation of growth
positive regulation of neuron projection development
regulation of developmental growth
positive regulation of neuron differentiation
positive regulation of cell projection organization
regulation of cell growth
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
regulation of growth
protein ubiquitination
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
protein modification by small protein conjugation
regulation of neurogenesis
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
protein modification by small protein conjugation or removal
negative regulation of cell death
regulation of anatomical structure morphogenesis
positive regulation of cellular component organization
positive regulation of developmental process
generation of neurons
regulation of apoptotic process
regulation of programmed cell death
neurogenesis
regulation of cell death