RNF185

Gene Information

Official Symbol: RNF185
Official Name: ring finger protein 185
Aliases and Previous Symbols: N/A
Entrez ID: 91445
UniProt: Q96GF1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521). {ECO:0000269|PubMed:21931693, ECO:0000269|PubMed:24019521, ECO:0000269|PubMed:27485036}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12784
Expression level (log2 read counts): 5.02

Expression Distribution

ubiquitin-like protein conjugating enzyme binding
Derlin-1 retrotranslocation complex
ER-associated misfolded protein catabolic process
positive regulation of ERAD pathway
endoplasmic reticulum mannose trimming
protein demannosylation
protein alpha-1,2-demannosylation
endoplasmic reticulum quality control compartment
cellular response to misfolded protein
response to misfolded protein
protein quality control for misfolded or incompletely synthesized proteins
regulation of ERAD pathway
protein deglycosylation
positive regulation of response to endoplasmic reticulum stress
protein autoubiquitination
ubiquitin-dependent ERAD pathway
ubiquitin binding
regulation of response to endoplasmic reticulum stress
ERAD pathway
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of cellular protein catabolic process
cellular response to topologically incorrect protein
mitochondrial outer membrane
regulation of proteasomal protein catabolic process
response to topologically incorrect protein
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
ubiquitin protein ligase activity
regulation of cellular protein catabolic process
response to endoplasmic reticulum stress
process utilizing autophagic mechanism
autophagy
protein-containing complex binding
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
glycoprotein metabolic process