RNF19A

Gene Information

Official Symbol: RNF19A
Official Name: ring finger protein 19A, RBR E3 ubiquitin protein ligase
Aliases and Previous Symbols: N/A
Entrez ID: 25897
UniProt: Q9NV58
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14161
Expression level (log2 read counts): 4.83

Expression Distribution

Screen	Score
TRAIL 5ng/ml R00 exp35	-3.01
JQ1 0.8μM R08 exp435	-1.74
Trimetrexate 0.03μM R08 exp535	2.17

regulation of protein catabolic process at postsynapse, modulating synaptic transmission
postsynaptic modulation of chemical synaptic transmission
ubiquitin conjugating enzyme binding
hippocampal mossy fiber to CA3 synapse
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
postsynapse
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
ubiquitin ligase complex
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
ubiquitin protein ligase activity
regulation of cellular protein catabolic process
protein polyubiquitination
transcription factor binding
glutamatergic synapse
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
microtubule cytoskeleton organization
centrosome
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
microtubule-based process
protein catabolic process
protein ubiquitination
regulation of proteolysis
protein modification by small protein conjugation
regulation of cellular catabolic process