RNF207

Gene Information

Official Symbol: RNF207
Official Name: ring finger protein 207
Aliases and Previous Symbols: N/A
Entrez ID: 388591
UniProt: Q6ZRF8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. {ECO:0000269|PubMed:25281747}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4974
Expression level (log2 read counts): 2.77

Expression Distribution

Screen	Score
Lead acetate 2000μM R08 exp497	-1.93
HMS-I1 10μM R06 exp256	-1.71
Pterostilbene 16μM R02 exp78	1.71

regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
regulation of heart looping
positive regulation of atrial cardiac muscle cell action potential
positive regulation of membrane repolarization during cardiac muscle cell action potential
positive regulation of ventricular cardiac muscle cell action potential
positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential
positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
positive regulation of cardiac conduction
positive regulation of actin filament-based movement
positive regulation of delayed rectifier potassium channel activity
regulation of membrane repolarization during ventricular cardiac muscle cell action potential
positive regulation of cardiac muscle cell contraction
regulation of membrane repolarization during cardiac muscle cell action potential
regulation of atrial cardiac muscle cell action potential
regulation of membrane repolarization during action potential
positive regulation of action potential
positive regulation of cardiac muscle contraction
positive regulation of striated muscle contraction
regulation of ventricular cardiac muscle cell action potential
positive regulation of voltage-gated potassium channel activity
regulation of delayed rectifier potassium channel activity
regulation of ventricular cardiac muscle cell membrane repolarization
positive regulation of potassium ion transmembrane transporter activity
regulation of cardiac muscle cell membrane repolarization
cell-cell signaling involved in cardiac conduction
regulation of cardiac muscle cell action potential
regulation of membrane repolarization
regulation of cardiac muscle cell contraction
positive regulation of potassium ion transmembrane transport
positive regulation of heart contraction
regulation of heart morphogenesis
regulation of actin filament-based movement
Hsp70 protein binding
cell communication involved in cardiac conduction
positive regulation of muscle contraction
positive regulation of potassium ion transport
regulation of action potential
regulation of potassium ion transmembrane transporter activity