RNF5

Gene Information

Official Symbol: RNF5
Official Name: ring finger protein 5
Aliases and Previous Symbols: N/A
Entrez ID: 6048
UniProt: Q99942
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. {ECO:0000269|PubMed:11329381, ECO:0000269|PubMed:12861019, ECO:0000269|PubMed:16176924, ECO:0000269|PubMed:19269966, ECO:0000269|PubMed:19285439}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8166
Expression level (log2 read counts): 4.49

Expression Distribution

ubiquitin-like protein conjugating enzyme binding
Derlin-1 retrotranslocation complex
ER-associated misfolded protein catabolic process
endoplasmic reticulum mannose trimming
protein alpha-1,2-demannosylation
protein demannosylation
endoplasmic reticulum quality control compartment
cellular response to misfolded protein
response to misfolded protein
protein quality control for misfolded or incompletely synthesized proteins
protein deglycosylation
regulation of autophagosome assembly
protein K63-linked ubiquitination
regulation of vacuole organization
protein destabilization
protein K48-linked ubiquitination
ubiquitin-dependent ERAD pathway
negative regulation of autophagy
ERAD pathway
mitochondrial membrane
cellular response to topologically incorrect protein
regulation of macroautophagy
response to topologically incorrect protein
regulation of organelle assembly
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
negative regulation of cellular catabolic process
response to endoplasmic reticulum stress
protein-containing complex binding
regulation of protein stability
protein polyubiquitination
negative regulation of catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of autophagy
proteasomal protein catabolic process
glycoprotein metabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process