ROPN1

Entrez Summary: N/A
UniProt Summary: Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. {ECO:0000250|UniProtKB:Q9ESG2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sperm capacitation
protein localization to cilium
sperm motility
flagellated sperm motility
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
spermatid development
spermatid differentiation
cell maturation
developmental maturation
germ cell development
cellular process involved in reproduction in multicellular organism
cilium organization
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
protein localization to organelle
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
identical protein binding
cell motility
localization of cell
plasma membrane bounded cell projection organization
cell projection organization
locomotion
reproductive process
reproduction
regulation of protein phosphorylation
movement of cell or subcellular component
cellular protein localization
regulation of phosphorylation
cellular macromolecule localization
cell development
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process