RPAP2

Entrez Summary: N/A
UniProt Summary: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 383/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	17/28
bone	9/26
breast	16/33
central nervous system	22/56
cervix	1/4
colorectal	10/17
esophagus	7/13
fibroblast	0/1
gastric	10/16
kidney	6/21
liver	9/20
lung	46/75
lymphocyte	12/16
ovary	14/26
pancreas	14/24
peripheral nervous system	9/16
plasma cell	12/15
prostate	0/1
skin	13/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	11/29
uterus	3/5

Expression Distribution

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.87
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.84
CyclicAMP 200μM R08 exp475	2.19

RNA polymerase core enzyme binding
dephosphorylation of RNA polymerase II C-terminal domain
RNA polymerase II CTD heptapeptide repeat phosphatase activity
RNA polymerase II, holoenzyme
protein serine/threonine phosphatase activity
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
protein dephosphorylation
dephosphorylation
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleolus
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression