RPRD2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Methotrexate 0.01μM R08 exp501	-2.06
Lead acetate 2000μM R08 exp498 no dilution day6	-1.73
Bortezomib 0.005μM R00 exp6	1.72
Docetaxel 0.002μM R01 exp45	1.93
Cerivastatin 0.15μM R05 exp226	1.97
Oligomycin-A 2μM R00 exp25	2.12
TRAIL 50ng/ml R00 exp36	2.51
TRAIL 5ng/ml R00 exp35	2.89
Betulinic acid 10 to 15μM on day4 R05 exp222	3.26

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
RPRD1B	0.421
CDC73	0.421

RNA polymerase II, holoenzyme
RNA polymerase II complex binding
snRNA transcription by RNA polymerase II
snRNA transcription
mRNA 3-end processing
ncRNA transcription
RNA 3-end processing
mRNA processing
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression