RPS6KA5
Gene Information
- Official Symbol: RPS6KA5
- Official Name: ribosomal protein S6 kinase A5
- Aliases and Previous Symbols: N/A
- Entrez ID: 9252
- UniProt: O75582
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase C |
| Pkinase Tyr |
| Kdo |
GO Terms
| histone H2A-S1 phosphorylation |
| histone H3-S28 phosphorylation |
| histone H2A phosphorylation |
| histone H3-S10 phosphorylation |
| positive regulation of histone phosphorylation |
| histone-serine phosphorylation |
| regulation of histone phosphorylation |
| positive regulation of CREB transcription factor activity |
| histone phosphorylation |
| positive regulation of histone acetylation |
| positive regulation of peptidyl-lysine acetylation |
| positive regulation of protein acetylation |
| epidermal growth factor receptor signaling pathway |
| regulation of histone acetylation |
| regulation of peptidyl-lysine acetylation |
| ERBB signaling pathway |
| regulation of protein acetylation |
| positive regulation of histone modification |
| interleukin-1-mediated signaling pathway |
| positive regulation of chromatin organization |
| stimulatory C-type lectin receptor signaling pathway |
| innate immune response activating cell surface receptor signaling pathway |
| regulation of histone modification |
| positive regulation of NF-kappaB transcription factor activity |
| peptidyl-serine phosphorylation |
| cellular response to interleukin-1 |
| positive regulation of chromosome organization |
| regulation of chromatin organization |
| peptidyl-serine modification |
| response to interleukin-1 |
| magnesium ion binding |
| innate immune response-activating signal transduction |
| protein kinase activity |
| activation of innate immune response |
| axon guidance |
| positive regulation of DNA-binding transcription factor activity |
| neuron projection guidance |
| negative regulation of cytokine production |
| positive regulation of innate immune response |
| regulation of chromosome organization |
| positive regulation of response to biotic stimulus |
| protein serine/threonine kinase activity |
| histone modification |
| axonogenesis |
| covalent chromatin modification |
| axon development |
| regulation of DNA-binding transcription factor activity |
| cell morphogenesis involved in neuron differentiation |
| immune response-activating cell surface receptor signaling pathway |
| regulation of innate immune response |
| positive regulation of defense response |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| inflammatory response |
| positive regulation of multi-organism process |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of response to biotic stimulus |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| positive regulation of organelle organization |
| activation of immune response |
| neuron projection development |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| chromatin organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of defense response |
| regulation of multi-organism process |
| neuron development |
| cellular component morphogenesis |
| positive regulation of immune response |
| peptidyl-amino acid modification |
| protein phosphorylation |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| chromosome organization |
| regulation of response to external stimulus |
| response to cytokine |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8151
- Expression level (log2 read counts): 6.02
Expression Distribution
RPS6KA5 Expression in NALM6 Cells: 6.02
