RSBN1

Entrez Summary: N/A
UniProt Summary: Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture. {ECO:0000250|UniProtKB:Q80T69}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.01μM R05 exp235	1.72
Cytochalasin-B 5μM R07 exp349	1.76
Ammonium tetrathiomolybdate 10μM R08 exp448	1.78
Myriocin 25μM R06 exp293	1.79
Atovaquone 15μM R08 exp451	1.82
IWR1 50μM R08 exp495	1.85
Cadmium 60μM R08 exp462	1.9
CyclicAMP 200μM R08 exp475	1.94
Ethambutol 25μM R08 exp481	2.49
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.58

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dioxygenase activity
chromatin organization
oxidation-reduction process
chromosome organization