RSPO2

Entrez Summary: N/A
UniProt Summary: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of odontogenesis of dentin-containing tooth
negative regulation of odontogenesis
trachea cartilage morphogenesis
lung growth
trachea cartilage development
trachea morphogenesis
regulation of odontogenesis of dentin-containing tooth
trachea development
epithelial tube branching involved in lung morphogenesis
regulation of odontogenesis
embryonic hindlimb morphogenesis
cartilage morphogenesis
dopaminergic neuron differentiation
embryonic forelimb morphogenesis
negative regulation of animal organ morphogenesis
hindlimb morphogenesis
frizzled binding
forelimb morphogenesis
lung morphogenesis
bone mineralization
biomineral tissue development
biomineralization
organ growth
embryonic appendage morphogenesis
embryonic limb morphogenesis
osteoblast differentiation
branching morphogenesis of an epithelial tube
positive regulation of canonical Wnt signaling pathway
appendage morphogenesis
limb morphogenesis
morphogenesis of a branching epithelium
morphogenesis of a branching structure
lung development
heparin binding
cartilage development
respiratory tube development
positive regulation of Wnt signaling pathway
limb development
appendage development
respiratory system development