RXRA

Gene Information

Official Symbol: RXRA
Official Name: retinoid X receptor alpha
Aliases and Previous Symbols: N/A
Entrez ID: 6256
UniProt: P19793
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:11162439, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:20215566}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5284
Expression level (log2 read counts): 0.75

Expression Distribution

Screen	Score
Resveratrol 16μM R03 exp147	-1.86
Torin1 0.08μM R02 exp82	-1.78
5-Fluorouracil 20μM R00 exp2	-1.75

Nuc recep-AF1
Hormone recep
zf-C4

positive regulation of translational initiation by iron
vitamin D response element binding
regulation of translational initiation by iron
DBD domain binding
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
regulation of branching involved in prostate gland morphogenesis
retinoic acid-responsive element binding
peroxisome proliferator activated receptor signaling pathway
LBD domain binding
prostate glandular acinus development
epithelial cell differentiation involved in prostate gland development
cardiac muscle cell proliferation
vitamin D receptor binding
striated muscle cell proliferation
retinoic acid receptor signaling pathway
ventricular cardiac muscle cell differentiation
muscle cell proliferation
nuclear receptor binding
retinoic acid binding
cardiac muscle tissue growth
heart growth
bile acid and bile salt transport
positive regulation of translational initiation
modulation by virus of host morphology or physiology
maternal placenta development
embryo implantation
glandular epithelial cell differentiation
modification by symbiont of host morphology or physiology
prostate gland development
nuclear receptor activity
ventricular cardiac muscle tissue morphogenesis
peptide binding
steroid hormone receptor activity
ventricular cardiac muscle tissue development
regulation of morphogenesis of a branching structure
maternal process involved in female pregnancy
cardiac muscle tissue morphogenesis
chromatin DNA binding
RNA polymerase II transcription factor complex
cardiac ventricle morphogenesis