SAG

Entrez Summary: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G- proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049). {ECO:0000250|UniProtKB:P08168, ECO:0000305|PubMed:9565049}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Arrestin C
Arrestin N

opsin binding
rhodopsin mediated signaling pathway
G protein-coupled receptor internalization
phototransduction, visible light
desensitization of G protein-coupled receptor signaling pathway
negative adaptation of signaling pathway
adaptation of signaling pathway
regulation of rhodopsin mediated signaling pathway
protein phosphatase inhibitor activity
phosphoprotein binding
phototransduction
detection of visible light
negative regulation of G protein-coupled receptor signaling pathway
photoreceptor inner segment
detection of light stimulus
negative regulation of phosphoprotein phosphatase activity
photoreceptor outer segment
receptor internalization
negative regulation of protein dephosphorylation
G protein-coupled receptor binding
receptor metabolic process
negative regulation of phosphatase activity
negative regulation of dephosphorylation
cellular response to light stimulus
regulation of phosphoprotein phosphatase activity
detection of external stimulus
detection of abiotic stimulus
regulation of protein dephosphorylation
regulation of G protein-coupled receptor signaling pathway
cellular response to radiation
regulation of phosphatase activity
regulation of dephosphorylation
receptor-mediated endocytosis
response to light stimulus
cellular response to environmental stimulus
cellular response to abiotic stimulus
response to radiation
negative regulation of hydrolase activity
endocytosis
negative regulation of phosphate metabolic process