SCARA3
Gene Information
- Official Symbol: SCARA3
- Official Name: scavenger receptor class A member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 51435
- UniProt: Q6AZY7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation. {ECO:0000269|PubMed:9580669}.
Pfam Domains GO Terms
Pfam Domains
| Collagen |
GO Terms
| toll-like receptor 3 signaling pathway |
| complement activation, lectin pathway |
| UV protection |
| chondrocyte morphogenesis involved in endochondral bone morphogenesis |
| chondrocyte morphogenesis |
| growth plate cartilage chondrocyte morphogenesis |
| growth plate cartilage morphogenesis |
| mannose binding |
| chondrocyte development involved in endochondral bone morphogenesis |
| growth plate cartilage chondrocyte differentiation |
| cartilage morphogenesis |
| chondrocyte differentiation involved in endochondral bone morphogenesis |
| growth plate cartilage development |
| endochondral bone growth |
| chondrocyte development |
| cartilage development involved in endochondral bone morphogenesis |
| bone growth |
| scavenger receptor activity |
| collagen trimer |
| endochondral bone morphogenesis |
| chondrocyte differentiation |
| organ growth |
| toll-like receptor signaling pathway |
| bone morphogenesis |
| pattern recognition receptor signaling pathway |
| response to UV |
| cartilage development |
| complement activation |
| bone development |
| connective tissue development |
| extracellular matrix |
| innate immune response-activating signal transduction |
| skeletal system morphogenesis |
| activation of innate immune response |
| response to light stimulus |
| positive regulation of innate immune response |
| humoral immune response |
| positive regulation of response to biotic stimulus |
| collagen-containing extracellular matrix |
| response to oxidative stress |
| developmental growth |
| growth |
| response to radiation |
| regulation of innate immune response |
| positive regulation of defense response |
| skeletal system development |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| endocytosis |
| cell morphogenesis involved in differentiation |
| immune response-activating signal transduction |
| tissue morphogenesis |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| Golgi membrane |
| activation of immune response |
| import into cell |
| calcium ion binding |
| cell morphogenesis |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| cellular component morphogenesis |
| positive regulation of immune response |
| endoplasmic reticulum membrane |
| defense response to other organism |
| animal organ morphogenesis |
| endoplasmic reticulum |
| immune effector process |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| extracellular space |
| cell development |
| regulation of immune system process |
| tissue development |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Wortmannin 5μM R00 exp38 | -1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10421
- Expression level (log2 read counts): 0.47
Expression Distribution
SCARA3 Expression in NALM6 Cells: 0.47