SCN4A
Gene Information
- Official Symbol: SCN4A
- Official Name: sodium voltage-gated channel alpha subunit 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 6329
- UniProt: P35499
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008].
- UniProt Summary: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle. {ECO:0000269|PubMed:15318338, ECO:0000269|PubMed:16890191}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3272
- Expression level (log2 read counts): 2.36
SCN4A Expression in NALM6 Cells: 2.36
