SCN8A

• Official Symbol: SCN8A
• Official Name: sodium voltage-gated channel alpha subunit 8
• Aliases and Previous Symbols: N/A
• Entrez ID: 6334
• UniProt: Q9UQD0
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
• UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 6236
• Expression level (log2 read counts): 1.87

Expression Distribution

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SCN8A Expression in NALM6 Cells: 1.87