SEC61B

Gene Information

Official Symbol: SEC61B
Official Name: SEC61 translocon subunit beta
Aliases and Previous Symbols: N/A
Entrez ID: 10952
UniProt: P60468
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Necessary for protein translocation in the endoplasmic reticulum.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.2μM R03 exp106	1.72
Arsenate 40μM R06 exp264	1.74
Rotenone 20μM R00 exp34	1.84
Hippuristanol 0.12μM R08 exp488	1.89
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.01

Global Fraction of Cell Lines Where Essential: 22/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	4/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	2/20
lung	1/75
lymphocyte	0/16
ovary	2/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1810
Expression level (log2 read counts): 5.95

Expression Distribution

Gene	Correlation
SEC63	0.576
ALG5	0.489
MANF	0.46
RPN2	0.431
TMED10	0.424
ROMO1	0.412
UBE2G2	0.4

endoplasmic reticulum Sec complex
epidermal growth factor binding
posttranslational protein targeting to membrane, translocation
Sec61 translocon complex
SRP-dependent cotranslational protein targeting to membrane, translocation
P-P-bond-hydrolysis-driven protein transmembrane transporter activity
posttranslational protein targeting to endoplasmic reticulum membrane
retrograde protein transport, ER to cytosol
endoplasmic reticulum to cytosol transport
ARF guanyl-nucleotide exchange factor activity
protein exit from endoplasmic reticulum
intracellular protein transmembrane transport
protein transmembrane transport
ubiquitin-dependent ERAD pathway
ERAD pathway
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
protein targeting to membrane
response to endoplasmic reticulum stress
establishment of protein localization to membrane
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
protein targeting
establishment of protein localization to organelle
protein localization to membrane
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein localization to organelle
cellular macromolecule catabolic process
endoplasmic reticulum membrane
intracellular protein transport
response to organonitrogen compound
endoplasmic reticulum