SERP1

Entrez Summary: N/A
UniProt Summary: Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Fluvastatin 2.2μM R06 exp282	1.91
Thapsigargin 0.005μM R07 exp407	2.11

positive regulation of growth hormone secretion
regulation of growth hormone secretion
multicellular organism aging
ribosome
positive regulation of organ growth
cytoplasmic microtubule
IRE1-mediated unfolded protein response
positive regulation of insulin secretion
muscle organ morphogenesis
post-embryonic development
plasma membrane organization
regulation of organ growth
positive regulation of peptide hormone secretion
endoplasmic reticulum unfolded protein response
glucose metabolic process
positive regulation of translation
cellular response to unfolded protein
positive regulation of hormone secretion
cellular response to topologically incorrect protein
positive regulation of cellular amide metabolic process
hexose metabolic process
response to unfolded protein
positive regulation of developmental growth
regulation of insulin secretion
response to topologically incorrect protein
monosaccharide metabolic process
regulation of peptide hormone secretion
protein glycosylation
response to endoplasmic reticulum stress
macromolecule glycosylation
positive regulation of growth
glycosylation
regulation of hormone secretion
positive regulation of protein secretion
aging
positive regulation of peptide secretion
muscle organ development
glycoprotein biosynthetic process
regulation of developmental growth
regulation of translation