SETDB2

Entrez Summary: N/A
UniProt Summary: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269|PubMed:20404330}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Hydroxyurea 15μM R06 exp289	-1.88
Actinomycin-D 0.001μM R00 exp3	1.82

histone methyltransferase activity (H3-K9 specific)
left/right axis specification
histone H3-K9 methylation
histone H3-K9 modification
left/right pattern formation
heart looping
embryonic heart tube morphogenesis
determination of heart left/right asymmetry
histone lysine methylation
embryonic heart tube development
axis specification
peptidyl-lysine methylation
histone methylation
determination of left/right symmetry
determination of bilateral symmetry
chromosome
specification of symmetry
protein alkylation
protein methylation
heart morphogenesis
macromolecule methylation
chromosome segregation
embryonic organ morphogenesis
epithelial tube morphogenesis
methylation
peptidyl-lysine modification
regionalization
histone modification
covalent chromatin modification
morphogenesis of an epithelium
embryonic organ development
pattern specification process
cell division
heart development
tissue morphogenesis
embryonic morphogenesis
tube morphogenesis
mitotic cell cycle
chromatin organization
zinc ion binding