SGK3

Gene Information

Official Symbol: SGK3
Official Name: serum/glucocorticoid regulated kinase family member 3
Aliases and Previous Symbols: N/A
Entrez ID: 23678
UniProt: Q96BR1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. {ECO:0000269|PubMed:12054501, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12632189, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16888620, ECO:0000269|PubMed:17167223, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:19293151, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:21865597}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16729
Expression level (log2 read counts): 4.3

Expression Distribution

Screen	Score
BI-2536 0.02μM R03 exp96	-1.79
LLY-283 2.6μM R06 exp290	1.73

Pkinase Tyr
PX
Pkinase C
Pkinase

chloride channel regulator activity
sodium channel regulator activity
negative regulation of signal transduction in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
calcium channel regulator activity
potassium channel regulator activity
regulation of extrinsic apoptotic signaling pathway in absence of ligand
phosphatidylinositol binding
negative regulation of extrinsic apoptotic signaling pathway
recycling endosome
regulation of extrinsic apoptotic signaling pathway
peptidyl-serine phosphorylation
peptidyl-serine modification
negative regulation of apoptotic signaling pathway
protein kinase activity
early endosome
protein serine/threonine kinase activity
regulation of apoptotic signaling pathway
regulation of cell growth
regulation of DNA-binding transcription factor activity
regulation of growth
regulation of cell migration
peptidyl-amino acid modification
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of cell motility
ion transmembrane transport
protein phosphorylation
regulation of locomotion
negative regulation of cell death
regulation of cellular component movement
negative regulation of signal transduction
transmembrane transport
phosphorylation
negative regulation of cell communication
negative regulation of signaling
ion transport
ATP binding
regulation of apoptotic process
regulation of programmed cell death