SH2D2A
Gene Information
- Official Symbol: SH2D2A
- Official Name: SH2 domain containing 2A
- Aliases and Previous Symbols: N/A
- Entrez ID: 9047
- UniProt: Q9NP31
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
- UniProt Summary: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4366
- Expression level (log2 read counts): 1.89
SH2D2A Expression in NALM6 Cells: 1.89
