SHMT1

Entrez Summary: This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
UniProt Summary: Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160). {ECO:0000269|PubMed:24698160, ECO:0000269|PubMed:8505317}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

L-allo-threonine aldolase activity
glycine biosynthetic process from serine
response to tetrahydrofolate
glycine hydroxymethyltransferase activity
cellular response to tetrahydrofolate
cobalt ion binding
serine binding
dTMP metabolic process
glycine biosynthetic process
dTMP biosynthetic process
L-serine catabolic process
carnitine biosynthetic process
pyrimidine deoxyribonucleoside monophosphate biosynthetic process
pyrimidine deoxyribonucleoside monophosphate metabolic process
amino-acid betaine biosynthetic process
pyrimidine deoxyribonucleotide biosynthetic process
deoxyribonucleoside monophosphate biosynthetic process
tetrahydrofolate interconversion
purine nucleobase biosynthetic process
deoxyribose phosphate biosynthetic process
L-serine metabolic process
2-deoxyribonucleotide biosynthetic process
deoxyribonucleoside monophosphate metabolic process
carnitine metabolic process
serine family amino acid catabolic process
deoxyribonucleotide biosynthetic process
translation repressor activity, mRNA regulatory element binding
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleoside monophosphate metabolic process
serine family amino acid biosynthetic process
amino acid binding
amino-acid betaine metabolic process
glycine metabolic process
tetrahydrofolate metabolic process
nucleobase biosynthetic process
folic acid metabolic process
pyrimidine deoxyribonucleotide metabolic process
purine nucleobase metabolic process
mRNA 5-UTR binding
one-carbon metabolic process