SLC14A2

Entrez Summary: N/A
UniProt Summary: Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. {ECO:0000269|PubMed:11502588, ECO:0000269|PubMed:8647271}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Zebularine 20μM R07 exp423	-1.97
Olaparib 4μM R08 exp512	-1.89
SNS-032 25μM R07 exp401	-1.74
SGC0946 7μM R03 exp151	1.82
Nicotinamide Riboside 100μM R03 exp139	1.9
NFN1 0.1μM R01 exp49	2.02
UM131593 0.1μM R01 exp58	2.07

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

urea channel activity
urea transmembrane transporter activity
urea transmembrane transport
urea transport
one-carbon compound transport
cell adhesion molecule binding
apical plasma membrane
transmembrane transport
integral component of plasma membrane
amide transport
nitrogen compound transport
membrane