SLC25A31

Entrez Summary: N/A
UniProt Summary: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility. {ECO:0000269|PubMed:17137571}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
ONC212 0.15μM R08 exp513	-1.85
Senexin-A 25μM R07 exp400	1.91

ATP:ADP antiporter activity
ADP transport
ATP transport
adenine nucleotide transport
purine ribonucleotide transport
purine nucleotide transport
nucleotide transport
carbohydrate derivative transport
motile cilium
organophosphate ester transport
drug transport
nucleobase-containing compound transport
mitochondrial inner membrane
organic anion transport
anion transport
response to drug
mitochondrion
transmembrane transport
ion transport
nitrogen compound transport