SLC35C2

Entrez Summary: N/A
UniProt Summary: May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells. {ECO:0000269|PubMed:20837470}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CCT251545 0.2μM R06 exp271	1.99
HMS-I1 1μM R01 exp46	2.02

UAA
TPT

UDP-glucose transmembrane transport
protein O-linked fucosylation
pyrimidine nucleotide-sugar transmembrane transport
nucleotide-sugar transmembrane transport
fucosylation
antiporter activity
positive regulation of Notch signaling pathway
transmembrane transporter activity
cis-Golgi network
endoplasmic reticulum-Golgi intermediate compartment membrane
carbohydrate derivative transport
endoplasmic reticulum-Golgi intermediate compartment
regulation of Notch signaling pathway
protein O-linked glycosylation
nucleobase-containing compound transport
protein glycosylation
macromolecule glycosylation
glycosylation
anion transmembrane transport
glycoprotein biosynthetic process
glycoprotein metabolic process
organic anion transport
anion transport
carbohydrate derivative biosynthetic process
ion transmembrane transport
Golgi apparatus
carbohydrate derivative metabolic process
transmembrane transport
ion transport
organonitrogen compound biosynthetic process
positive regulation of signal transduction
cellular macromolecule biosynthetic process
negative regulation of gene expression
macromolecule biosynthetic process
positive regulation of cell communication
positive regulation of signaling
nitrogen compound transport